Identifying and Ranking Causative Biochemical Biomarkers of Breast Cancer: A Mendelian Randomization Study – BMC Medicine
Analysis plan Our prospective plan was to perform a variety of two-sample univariate MR (UVMR) analyzes to examine the associations of each of the UKB biochemical biomarkers with global, ER-positive and ER-negative breast cancer causation. Once our UVMR analyzes showed significant associations, we performed further multivariate MR (MVMR) analyzes to adjust for known risk factors …