Fragments

Zombie viruses on a hijacking journey: how retroviral gene fragments affect embryonic cells

Zombie viruses on a hijacking journey: how retroviral gene fragments affect embryonic cells

In mouse stem cell nuclei, derepressed endoviral RNA molecules (purple) appear in the same locations as RNA polymerase II-containing condensates (green), as shown in this fluorescence microscopy image. Credit: Asimi et al. Old and dormant genome sequences have an unexpected impact on embryonic development. The mammalian genome contains retroviral sequences that are in an undead …

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Liver Cancer Detection Score Developed with Machine Learning Analysis of Blood Plasma DNA Fragments

Liver Cancer Detection Score Developed with Machine Learning Analysis of Blood Plasma DNA Fragments

NEW YORK – A team led by Johns Hopkins University has developed a circulating cell-free DNA (cfDNA) “fragmentome” and machine learning approach to boost the detection of hepatocellular carcinoma, suggesting the strategy can help monitor people with viral hepatitis, cirrhosis, non-alcoholic fatty liver disease (NAFLD) and other risk conditions. “Medical societies around the world recommend …

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