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Autism-linked gene discovered to shape nerve connections – Neuroscience News

Summary: The autism-linked Gabrb3 gene appears to shape the formation of normal and atypical neural connections in the brain. Source: Cornell University A gene linked to autism spectrum disorders plays a critical role in early brain development and may shape the formation of normal and atypical nerve connections in the brain, according to a new …

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Image displaying impeded interneuron development.

‘Assembloids’ expose autism-linked genes that impede neuron development | Spectrum | Autism Research News

New platform: CRISPR experimentation reveals genes, such as LNPK, that impede the development of interneurons when they are absent from forebrain assembloid models. About 10% of genes strongly linked to autism and other neurodevelopmental conditions interfere with the development of interneurons, according to unpublished findings published on bioRxiv. The study gleaned the effects of genes …

‘Assembloids’ expose autism-linked genes that impede neuron development | Spectrum | Autism Research News Read More »

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World’s largest autism whole-genome sequencing study reveals 134 autism-linked genes

Summary: The researchers identified 134 genes associated with autism and a range of genetic alterations associated with ASDs. Notably, the study identified changes in copy number variations with likely associations with ASDs, including autism-associated variants in 14% of people on the autism spectrum. Source: Hospital for sick children Researchers at the Hospital for Sick Children …

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