autism

Whole-genome treasure links new genes and variants to autism |  Spectrum |  Autism Research News

Whole-genome treasure links new genes and variants to autism | Spectrum | Autism Research News

The largest analysis to date of whole-genome sequences from people with autism links new genes and variants to the disease. The results and sequences – from 5,100 people with autism and 6,212 without – are on a cloud-based platform and are available to trained researchers. This effort is the latest advancement of the ongoing MSSNG …

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Community newsletter: Sexual prejudice; formation of synapses; convergence of genes | Spectrum | Autism Research News

Illustration by Laurene Boglio Three new autism research threads drew a slew of congratulatory tweets this week. Let’s dive in! A 16-part thread, by Alessandro Gozzi, a senior scientist at the Italian Institute of Technology in Rovereto, Italy, describes a mechanism behind the sex bias in autism, featured in a preprint his team published on …

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‘Assembloids’ expose autism-linked genes that impede neuron development | Spectrum | Autism Research News

New platform: CRISPR experimentation reveals genes, such as LNPK, that impede the development of interneurons when they are absent from forebrain assembloid models. About 10% of genes strongly linked to autism and other neurodevelopmental conditions interfere with the development of interneurons, according to unpublished findings published on bioRxiv. The study gleaned the effects of genes …

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Breakthrough in autism: New treatment dramatically improves social skills and brain function

The researchers anticipate that the success of the study will have positive implications for clinical treatment. The treatment caused neurological changes, including a decrease in inflammation and an increase in functionality, according to the researchers. A recent study from Tel Aviv University found that pressure chamber therapy significantly improved social skills and brain status in …

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The social behavior gene could be the key to understanding autism

The social behavior gene could be the key to understanding autism

Little is known about how social behavior develops in the early stages of life. But most animals, including humans, are born with an innate ability to socially interact or bond with others. And that contributes to lifelong success. Now, a new animal study points to a gene important for the early development of basic social …

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The gene that guides early social behaviors could hold the key to understanding autism

The gene that guides early social behaviors could hold the key to understanding autism

23 November 2022 12:00 Little is known about how social behavior develops in the early stages of life. But most animals, including humans, are born with an innate ability to socially interact or bond with others. And that contributes to lifelong success. To test whether environmental factors could influence social behavior, the researchers exposed zebrafish …

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Gene that guides early social behaviors may hold key to understanding autism – Neuroscience News

Summary: The TOP2a gene controls a network of genes that contribute to ASD. Drugs that suppress TOP2a during development can turn on a group of other genes that disrupt brain development and increase the risk of autism. Alterations in the TOP2a gene may be responsible for the social behavior difficulties associated with ASD. Source: University …

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The hunt for the disrupted brain signals behind autism

Part of understanding the underlying causes of autism spectrum disorders relies on determining which signaling patterns of cells in the brain are disrupted and when, during nervous system development, the disruption occurs. New research results from mouse models of genetic risk for autism support the idea that the loss of a specific gene interferes with …

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World’s largest autism whole-genome sequencing study reveals 134 autism-linked genes

Summary: The researchers identified 134 genes associated with autism and a range of genetic alterations associated with ASDs. Notably, the study identified changes in copy number variations with likely associations with ASDs, including autism-associated variants in 14% of people on the autism spectrum. Source: Hospital for sick children Researchers at the Hospital for Sick Children …

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