ALS

Scientists identify genetic variant causing ALS in some patients

Scientists identify genetic variant causing ALS in some patients

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Researchers from Nagoya University in Japan have identified a new genetic variant found in some patients with amyotrophic lateral sclerosis (ALS). Using human induced pluripotent stem (iPS) cells, they detailed the process by which this variant relates to ALS. The researchers say they expect this mechanism to be a new therapeutic target for the treatment …

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Slowing down ALS with speech: Study uses IBM AI to create digital biomarkers

Slowing down ALS with speech: Study uses IBM AI to create digital biomarkers

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The study​ EverythingALS is working with clinical research stakeholders from IBM Research, Massachusetts Institute of Technology, and Harvard University in a longitudinal study focused on early disease detection based on patterns scored in audiovisual sessions. The study includes more than 800 participants diagnosed with amyotrophic lateral sclerosis (ALS), caregivers, those suspected of developing ALS due …

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Developing an RNA-targeting strategy to fix the genetic cause of ALS and dementia – Neuroscience News

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Summary: A new compound eliminates pathogenic segments of RNA associated with ALS and dementia, and restores healthy neurons in mouse models. Source: University of Florida Scientists at the University of Florida (UF) Scripps Biomedical Research have developed a potential drug for a major cause of ALS and dementia that works by removing disease-causing RNA segments. …

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Genetic cause of ALS and dementia repaired by RNA targeting strategy developed at UF Scripps

Genetic cause of ALS and dementia repaired by RNA targeting strategy developed at UF Scripps

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UF Scripps Biomedical Research scientists have developed a potential drug for a major cause of ALS and dementia that works by removing disease-causing RNA segments. The compound restored the health of neurons in the lab and saved mice with disease. The potential drug is described this week in the scientific journal Proceedings of the National …

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