Proteome-expressing gene research shows reactive mode of communication housed in DNA

Proteome-expressing gene research shows reactive mode of communication housed in DNA

This month, Professor Franklin Pugh, Molecular Biology and Genetics, and researchers Chitvan Mittal grad, Olivia Lang grad and William KM Lai grad, discovered that inducible systems work in conjunction with constitutive systems to produce variable outputs in function of the “on” or “off” state of certain cofactors – this highlights new understandings of how the epigenome affects transcription in cells.

The team published their study “An Integrate SAGA and TFID PIC Assembly Pathway Selective For Poised and Induced Promoters” in the journal Genes and development.

The study used yeast as a model to determine the functionality of inducible systems within the genome dedicated to gene expression. Inducible systems are systems that are usually activated by environmental changes in the microenvironment. Pugh compared yeast to a simpler model to study the molecular machinery that regulates genes in humans.


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